Explore/Peru/PE CUS/Cusco to Puerto Maldonado — Interoceanic Highway Descent to the Amazon
PECusco, PeruChallengingPaved2-day tripMotoVault Pick

Cusco to Puerto Maldonado — Interoceanic Highway Descent to theAmazon.

Distance
500 km
Duration
2 days
Climb
2,800 m
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Curated by Rider · Updated Oct 2026
Overview

Cusco to Puerto Maldonado — Interoceanic Highway Descent to the Amazon.

The Interoceanic Highway drops from the thin air of Cusco at 3,400m to the steaming Amazon lowlands of Puerto Maldonado. Over two days the fully paved road crosses a 4,700m pass, spills through dense cloud forest past the old gold town of Quince Mil, and crosses the Inambari river into the rainforest of Madre de Dios. One of the great altitude-to-jungle transitions in South America.

Quick facts

SurfacePaved
Distance500 km
Days2
Total climb2,800 m
Fuel stops2 along route
DifficultyChallenging
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Day-by-day

2 days, 2 moods.

A suggested split across 2 days with 5 waypoints to discover along the way.
DAY 01
Cusco → Quince Mil
3 stops
Start
CuscoStart · Start in the Inca capital at 3,400m. Fuel and a full bike check: the road climbs over the Hualla-Hualla pass at 4,725m before the long descent to the jungle.
Fuel
UrcosFuel Stop · Last sizeable town on the altiplano and gateway to the sacred Apu Ausangate. Top up fuel; services thin out on the climb to the pass.
Overnight
Quince MilOvernight · Overnight at Quince Mil (620m), an old gold-rush settlement swallowed by cloud forest. One of the rainiest places in Peru - expect humidity after the cold passes.
DAY 02
Mazuko → Puerto Maldonado
2 stops
Fuel
MazukoFuel Stop · Frontier mining town where the road meets the Inambari river and the Amazon lowlands begin. Fuel, food and a change into lighter gear.
End
Puerto MaldonadoEnd · End at the Madre de Dios capital on the Tambopata river - gateway to the southern Amazon rainforest. Sea-level heat after a 3,400m start.

More routes in PE CUS

Cusco to Puno — La Raya Pass & the Ruta del SolPE CUS · 390 kmManu Road — Cusco to Pilcopata via AcjanacoPE CUS · 230 kmSacred Valley & Maras Salt Pans — Cusco CircuitPE CUS · 130 kmAbra Malaga — Cusco to Quillabamba Cloud ForestPE CUS · 200 km

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